TY - JOUR AU - Gong, Lei AU - Chen, Ping AU - Liu, Xianjun AU - Han, Ying AU - Zhou, Yanping AU - Zhang, Weidong AU - Li, Hong AU - Li, Chuanjia AU - Xie, Jiang PY - 2012 TI - Expressions of D2-40, CK19, galectin-3, VEGF and EGFR in papillary thyroid carcinoma JF - Gland Surgery; Vol 1, No 1 (May 10, 2012): Gland Surgery Y2 - 2012 KW - N2 - Objective: To investigate the expressions of D2-40, CK19, galectin-3, VEGF, and EGFR in papillary thyroid carcinoma and their clinical significances. Methods: The expressions of D2-40, CK19, galectin-3, VEGF, and EGFR in 38 cases of papillary thyroid carcinoma and 12 cases of thyroid papillary hyperplasia were detected by immunohistochemical staining. Results: The positive expression rates of D2-40, CK19, Galectin-3, VEGF and EGFR in patients with papillary thyroid carcinoma were all significantly higher than those in patients with thyroid papillary hyperplasia (all P<0.05). The expressions of D2-40, VEGF, and EGFR in papillary thyroid carcinoma with lymph node metastasis were significantly higher than those without lymph node metastasis (P<0.05). The expressions of GK19 and galectin-3 showed no significant differences between the papillary thyroid carcinomas with and without lymph node metastasis (P>0.05). Conclusions: The detection of D2-40, CK19, galectin-3, VEGF, and EGFR is helpful for the diagnosis and differential diagnosis of papillary thyroid carcinoma and thyroid papillary hyperplasia. UR - https://gs.amegroups.org/article/view/606