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Clinical study on surgical treatment of granulomatous lobular mastitis

  
@article{GS32844,
	author = {Chaojie Zhang and Shanshan Lei and Cheng Kong and Yuanzhen Tan and Xu Dai and Jie He and Qiang Xiao and Shulin Huang},
	title = {Clinical study on surgical treatment of granulomatous lobular mastitis},
	journal = {Gland Surgery},
	volume = {8},
	number = {6},
	year = {2019},
	keywords = {},
	abstract = {Background: The etiology and pathogenesis of granulomatous lobular mastitis (GLM) remain unknown, with no unified evaluation criteria or standard treatments. This study aimed to assess the etiology and features of GLM, as well as the effects of surgery (lesion excision + stage I breast reconstruction; LE + BR) for GLM.
Methods: This study evaluated 178 female GLM patients retrospectively in 2006–2015. The surgery and non-surgery groups included 164 and 14 patients, respectively. All patients received conservative therapy (traditional Chinese medicine combined with regional wet compress and pus drainage). In addition, the surgery group (n=164) underwent LE + BR. Clinical data, including disease course, causes, lesion size, marital status, and treatment approaches, were assessed.
Results: Follow-up was 13–117 months. Seventy-five of the 178 patients had no overt causes (42.1%); meanwhile, 63 (35.4%) and 16 (9.0%) had congenital nipple retraction and a history of psychotropic drugs for >1 year, respectively. The surgery group showed lesions significantly shrunk (≤1 quadrant) with acute inflammation fully controlled; 8 showed recurrence, indicating a cure rate of 95.1% (156/164). In the non- surgery group, 4 cases showed relapse after 6–14 months (cure rate =71.4%; 10/14). Therefore, surgical treatment was significantly more efficient than non-surgical treatment (P=0.001). Kaplan-Meier survival curves for the two treatment types showed a significant difference in recurrence (log rank =11.84, P},
	issn = {2227-8575},	url = {https://gs.amegroups.org/article/view/32844}
}