TY - JOUR AU - Zhang, Ting-Ting AU - Qi, Xiu-Zhu AU - Chen, Jian-Ping AU - Shi, Rong-Liang AU - Wen, Shi-Shuai AU - Wang, Yu-Long AU - Ji, Qing-Hai AU - Shen, Qiang AU - Zhu, Yong-Xue AU - Qu, Ning PY - 2019 TI - The association between tumor’s location and cervical lymph nodes metastasis in papillary thyroid cancer JF - Gland Surgery; Vol 8, No 5 (October 29, 2019): Gland Surgery Y2 - 2019 KW - N2 - Background: Papillary thyroid cancer (PTC) has a strong propensity to metastasize to the cervical lymph nodes. Little was known currently about whether tumor’s location would influence the risk of lymph node metastasis in PTC. Methods: The study enrolled PTC patients who underwent primary surgical therapy in our center for small unifocal tumor. The tumor’s location was evaluated by ultrasound in three axes, three planes and 3D space. Logistic univariate and multivariate analysis were applied to explore the association between tumors’ location and the risk of lymph node metastasis in PTC. Different localization methods of thyroid tumors were evaluated using ROC curve. Results: Totally 1,266 PTC patients were enrolled in this study. Univariate and multivariate analyses showed that gender, age, tumor size and tumor’s location (in longitudinal axis, longitudinal sagittal plane, longitudinal coronal plane, sagittal coronal plane and 3D space) was associated with central lymph node dissection (CLND); gender, tumor size and tumor’s location (in longitudinal axis, coronal axis, longitudinal sagittal plane, longitudinal coronal plane, sagittal coronal plane and 3D space) was related with lateral lymph node dissection (LLND) (P Conclusions: Stereotactic localization showed the highest predictive value of lymph node metastasis. The middle posterior lateral, inferior anterior central, inferior posterior lateral and isthmus tumors were at a higher risk of CLNM when compared to other locations. For such patients, careful preoperative evaluation of nodal status should be done. UR - https://gs.amegroups.org/article/view/30615