@article{GS23194,
author = {Massimo Bongiovanni and Claudio Bellevicine and Giancarlo Troncone and Gerasimos P. Sykiotis},
title = {Approach to cytological indeterminate thyroid nodules},
journal = {Gland Surgery},
volume = {8},
number = {Suppl 2},
year = {2019},
keywords = {},
abstract = {The indeterminate thyroid nodules diagnosed by fine-needle aspiration cytology (FNAC) represents a problem for both cytopathologists and clinicians. The former sometimes use this diagnostic category as a sort of basket, putting in cases that they do not know exactly how to classify. The latter are faced with a highly variable risk of malignancy and consequently the management remains a challenge. On the histopathological side, the new WHO classification of tumors of the thyroid introduced the concept of tumors with uncertain and low malignant potential, and the concept of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP), whose prognosis and management are still to be completely elucidated. While the risk of malignancy of the indeterminate diagnostic category has decreased due to the re-classification of certain types of papillary thyroid carcinomas of the follicular variant into a low malignant potential form (the NIFTP), cases diagnosed cytologically as indeterminate will probably increase in the future to avoid false positive diagnosis. Thus, the indeterminate thyroid diagnostic category still remains a challenge, both at the diagnostic level and for its management. The new version of the Bethesda system for reporting thyroid cytopathology suggests managing these patients with a repeat FNA, diagnostic lobectomy and/or molecular testing.},
issn = {2227-8575}, url = {https://gs.amegroups.org/article/view/23194}
}