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Laparoscopic versus open 1-stage resection of synchronous liver metastases and primary colorectal cancer

	author = {Emre Gorgun and Pinar Yazici and Akin Onder and Cigdem Benlice and Hakan Yigitbas and Bora Kahramangil and Yunus Tasci and Erol Aksoy and Federico Aucejo and Cristiano Quintini and Charles Miller and Eren Berber},
	title = {Laparoscopic versus open 1-stage resection of synchronous liver metastases and primary colorectal cancer},
	journal = {Gland Surgery},
	volume = {6},
	number = {4},
	year = {2017},
	keywords = {},
	abstract = {Background: The aim of this study is to compare the perioperative and oncologic outcomes of open and laparoscopic approaches for concomitant resection of synchronous colorectal cancer and liver metastases. 
Methods: Between 2006 and 2015, all patients undergoing combined resection of primary colorectal cancer and liver metastases were included in the study (n=43). Laparoscopic and open groups were compared regarding clinical, perioperative and oncologic outcomes. 
Results: There were 29 patients in the open group and 14 patients in the laparoscopic group. The groups were similar regarding demographics, comorbidities, histopathological characteristics of the primary tumor and liver metastases. Postoperative complication rate (44.8% vs. 7.1%, P=0.016) was higher, and hospital stay (10 vs. 6.4 days, P=0.001) longer in the open compared to the laparoscopic group. Overall survival (OS) was comparable between the groups (P=0.10); whereas, disease-free survival (DFS) was longer in laparoscopic group (P=0.02). 
Conclusions: According to the results, in patients, whose primary colorectal cancer and metastatic liver disease was amenable to a minimally invasive resection, a concomitant laparoscopic approach resulted in less morbidity without compromising oncologic outcomes. This suggests that a laparoscopic approach may be considered in appropriate patients by surgeons with experience in both advanced laparoscopic liver and colorectal techniques.},
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