Article Abstract

Expressions of D2-40, CK19, galectin-3, VEGF and EGFR in papillary thyroid carcinoma

Authors: Lei Gong, Ping Chen, Xianjun Liu, Ying Han, Yanping Zhou, Weidong Zhang, Hong Li, Chuanjia Li, Jiang Xie

Abstract

Objective: To investigate the expressions of D2-40, CK19, galectin-3, VEGF, and EGFR in papillary
thyroid carcinoma and their clinical significances.
Methods: The expressions of D2-40, CK19, galectin-3, VEGF, and EGFR in 38 cases of papillary thyroid
carcinoma and 12 cases of thyroid papillary hyperplasia were detected by immunohistochemical staining.
Results: The positive expression rates of D2-40, CK19, Galectin-3, VEGF and EGFR in patients with
papillary thyroid carcinoma were all significantly higher than those in patients with thyroid papillary
hyperplasia (all P<0.05). The expressions of D2-40, VEGF, and EGFR in papillary thyroid carcinoma
with lymph node metastasis were significantly higher than those without lymph node metastasis (P<0.05).
The expressions of GK19 and galectin-3 showed no significant differences between the papillary thyroid
carcinomas with and without lymph node metastasis (P>0.05).
Conclusions: The detection of D2-40, CK19, galectin-3, VEGF, and EGFR is helpful for the diagnosis
and differential diagnosis of papillary thyroid carcinoma and thyroid papillary hyperplasia.

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