Thyrolipomatosis: an inquisitive rare entity
Case Report

Thyrolipomatosis: an inquisitive rare entity

Rajasekhar Vijay Rama Sanuvada1, Amit Kumar Chowhan1, Nandyala Rukmangadha1, Rashmi Patnayak1, Mutheeswariya Yootla2, Lakshmi Yadagiri Amancharla3

1Department of Pathology, 2Department of General Surgery, 3Department of Radiodiagnosis, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh 517507, India

Correspondence to: Amit Kumar Chowhan, M.D. Assistant Professor, Department of Pathology, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh 517507, India. Email:

Abstract: It is rare to find diffuse presence of mature adipose tissue inside thyroid gland which defines thyrolipomatosis. We report a case of a 32-year-old hyperthyroid female on suppression therapy since the past 2 years presenting with diffuse thyroid swelling. She underwent total thyroidectomy and the histopathology revealed features of thyrolipomatosis. As fat containing lesions of thyroid include not only non-neoplastic lesions but neoplasms also, including an occasional malignant one, rendering a correct diagnosis is essential.

Keywords: Histopathology; lipomatosis; thyroid gland; thyrolipoma

Submitted Sep 10, 2014. Accepted for publication Nov 11, 2014.

doi: 10.3978/j.issn.2227-684X.2014.11.02


Normally, adipose tissue is observed in the parathyroid, salivary glands, thymus, breasts and pancreas; however, it is unusual to detect adipose tissue in the thyroid gland. Fat containing lesions of thyroid are very rare with only a few cases described in the literature. Normal thyroid occasionally may show presence of mature adipocytes in perivascular and subcapsular area anteriorly (1). Various fat containing lesions described in literature are heterotopic adipocytic nests, intrathyroidal thymic or parathyroid lipoma, lymphocytic thyroiditis, amyloid goiter containing lipomatous tissue, adenolipoma, lipomatosis, encapsulated papillary carcinoma and liposarcoma (2). We report a rare case of thyrolipomatosis in a 32-year-old hyperthyroid female and discuss briefly the proposed theories of pathogenesis and differential diagnosis of fat containing thyroid lesions.


A 32-year-old female presented with midline neck swelling slowly increasing in size since the past 2 years. She complained of weight loss with normal appetite and sleep disturbance. There was no history of palpitation, tremor, sweating, menstrual irregularity, difficulty in swallowing or hoarseness of voice. Past history revealed that she was a known case of hyperthyroidism on suppression therapy of 10 mg/day neomercazole since past two years.

On examination pallor was seen without any signs of icterus. Local examination revealed diffuse thyromegaly measuring 5 cm × 4 cm involving both lobes, more prominent on right side. The mild tender swelling was soft in consistency, moving with deglutition. Clinical diagnosis was hyperthyroidism with toxic multinodular goiter.

Ultrasonogram (USG) showed diffusely enlarged thyroid gland with altered echotexture. Multiple nodular echogenic lesions were noted in right lobe, largest measuring 2.16 cm × 1.01 cm. Computed tomography (CT) scan revealed a diffuse heterogeneously enhancing soft tissue density lesion in the right lobe of thyroid infiltrating strap muscles, neck soft tissue and subcutaneous tissue. The right lobe mass had low density areas [–8 to –18 Hounsfield unit (HU)] with mass effect on oropharynx (Figure 1). No enlarged lymph nodes could be noted. Technetium-99m scan revealed hyperfunctioning enlarged thyroid gland with grossly enlarged right lobe.

Figure 1 CT coronal reformated image: heterogeneously enhancing mass (white arrow) in right lobe of thyroid with low density areas (–8 to –18 HU) and mass effect on oropharynx. CT, computed tomography; HU, Hounsfield unit.

Other investigations performed were indirect laryngoscopy which was normal and echocardiography revealed normal left ventricular function. Serum T3 was 12.1 ng/dL, T4 was 128.85 µg/dL and TSH 0.01 mIU/mL. Retroviral serology, HBsAg and HCV were non-reactive.

Fine needle aspiration cytology of right lobe of thyroid was performed which revealed hyperplastic follicular epithelial cells in clusters and attempted follicles with thin colloid in the background. An impression of colloid goiter was suggested.

The patient was taken up for total thyroidectomy under general anaesthesia. The total thyroidectomy specimen measured 11 cm × 5 cm × 2 cm and weighed 88 grams. External surface was grey brown. Cut section showed diffuse grey brown to yellowish areas (Figure 2). No focal lesions could be noted.

Figure 2 Gross photograph of total thyroidectomy specimen reveal large areas of yellowish adipose tissue with intervening relatively normal looking tan coloured thyroid parenchyma.

Microscopic examination revealed lobules of normal to colloid filled macro follicles lined by cuboidal cells separated by thin fibrous strands with intervening congested blood vessels, foci of haemorrhage and few hemosiderin pigment laden macrophages. In addition was found diffuse presence of mature adipose tissue in the interfollicular stroma without any cytological atypia (Figure 3). Neither lymphocytic collection, hurthle cells, amyloid nor papillary structures could be found. A histopathological diagnosis of thyrolipomatosis was made.

Figure 3 Photomicrograph showing mature adipocytes interposed between colloid filled normo to macrofollicles lined by thyroid follicular cells (H&E ×100).

Post surgery hormonal levels were TSH 13 mIU/mL, T4 74 µg/dL and T3 0.9 ng/dL. The patient was started on eltroxin 100 mg tablet once daily.


The presence of mature adipose tissue in thyroid is an uncommon occurrence. In most cases it is found in a subcapular location; most authors attribute this finding to inclusion of mesenchymal fat and sometimes muscle during embryologic development (1). Some authors think that adipose tissue is included in the thyroid gland during embryogenesis and that thyrolipoma is a true neoplasm with proliferation of fatty tissue (3).

Fat-containing lesions of the thyroid gland can broadly be categorized as (I) macroscopic mature fatty tissue containing lesions; and (II) lesions rich in microscopic intracellular fat vacuoles, or lesions that are referred to as clear cell rich or lipid-rich neoplasms (2,4). Occasionally, lipomas of cervical region may mimic thyroid nodules, particularly when they grow into the thyroid gland, but findings at multiplanar cross-sectional imaging can be used to resolve this issue in most cases (5).

Much rarer are mass lesions or tumours, containing fat and thyroid tissue mixed together, sometimes surrounded by a fibrous capsule. Such lesions have been variously termed as adenolipoma, thyrolipoma, thyrolipomatosis, lymphocytic thyroiditis, amyloid goiter, intrathyroid thymic or parathyroid lipoma and malignant tumors like liposarcoma and encapsulated papillary carcinoma (4,6). Preoperatively, fine-needle aspiration cytology may suggest a diagnosis of thyroid lipomatosis based on an abundance of fat cells in the smear (7). However in our case we didn’t find any fat cells and therefore it was reported as colloid goiter. The possible reason could be that we employed non aspiration technique and it requires good amount of suction pressure to extract adipose tissue.

Breek et al. (8) reported a case of thyrolipoma and thymolipoma and noted that thyroid and thymus arise from primitive foregut and added that the simultaneous appearance of these tumors suggested a disturbance in the development of the primitive foregut.

Metaplastic theory has both its supporters and refuters. Schröder and Böcker (6) believe in the origin of fat cells from stromal fibroblasts due to chronic tissue hypoxia is presumed responsible for the presence of fatty tissue in amyloid goitres. Massive steatosis of follicle cells, as seen in the lipid-rich variant of clear cell thyroid adenomas and carcinomas, is, however, claimed to most likely result from metaplastic transformation of neoplastic thyrocytes.

The origin of thyrolipoma is unclear; since there appears to be a proliferation of both fat and thyroid tissue, it may represent a hyperplasia of both the thyroid and mesenchymal tissue, or, conversely and less likely, the fat may represent a mesenchymal metaplasia. LiVolsi (4) believes the latter is unlikely since the cases reported indicate no associated fibrosis or inflammation, which is usual in fatty metaplasia in other organs, e.g., cystic fibrosis.

Some patients have been reported in whom amyloid goiter has been associated with fat. A few cases of adipose tissue admixed with thyroid have been described in which the entire gland is affected; these lesions have been called hamartomatous adiposity or adenolipomatosis (9).

An extremely unusual tumor has been reported by Vestfrid (10), this was a papillary thyroid carcinoma occurring in a 53-year-old woman. In many areas of the tumor the cores of the papillae were composed of mature adipose tissue.

According to Ge et al. (11) parathyroid lipoma should be kept in mind in the differential diagnosis of thyrolipoma, especially in patients with extrathyroidal nodules and positive parathyroid scans. In these cases, the presence of cytoplasmic glycogen supports the parathyroid tissue. Sheikh and Massloom (12) described a case of lipoadenoma where the adipose tissue was abundant and little viable native tissue leading to a diagnostic dilemma about its origin, whether is it from thyroid or parathyroid. The final diagnosis of thyroid origin was based on immunohistochemical positivity for thyroglobulin marker.

Final remarks

This case has been presented because of its rare occurrence. These lesions are considered to be benign and treated surgically.


The authors thank senior technical staff Mrs. Ushanandini and Mr. Ramanna for excellent histopathological sections.

Disclosure: The authors declare no conflict of interest.


  1. Kitagawa W, Kameyama K, Tamai S, et al. Adenolipoma of the thyroid gland: report of a case. Surg Today 2004;34:593-6. [PubMed]
  2. Borges A, Catarino A. Case 53: adenolipoma of the thyroid gland. Radiology 2002;225:746-50. [PubMed]
  3. Rosai J, Carcangiu ML, DeLellis RA. eds. Tumors of the thyroid gland. Atlas of Tumor Pathology. Washington DC: Armed Forces Institute of Pathology, 1992.
  4. LiVolsi VA. Surgical pathology of the thyroid. In: Bennington JL. eds. Major problems in pathology series. Philadelphia, PA: Saunders, 1990:323-50.
  5. Leonidas JR, Goldman JM, Wheeler MF. Cervical lipomas masquerading as thyroid nodules. JAMA 1985;253:1436-7. [PubMed]
  6. Schröder S, Böcker W. Lipomatous lesions of the thyroid gland: a review. Appl Pathol 1985;3:140-9. [PubMed]
  7. Pradeep PV, Kumar R, Ragavan M, et al. Diffuse lipomatosis of thyroid with hyperthyroidism. J Postgrad Med 2010;56:35-6. [PubMed]
  8. Breek JK, Vallaeys JH, Rutsaert RR. Simultaneous presentation of a thyrolipoma and a thymolipoma in a young man. Eur J Surg 1997;163:941-3. [PubMed]
  9. Simha MR, Doctor VM. Adenolipomatosis of the thyroid gland. Indian J Cancer 1983;20:215-7. [PubMed]
  10. Vestfrid MA. Papillary carcinoma of the thyroid gland with lipomatous stroma: report of a peculiar histological type of thyroid tumour. Histopathology 1986;10:97-100. [PubMed]
  11. Ge Y, Luna MA, Cowan DF, et al. Thyrolipoma and thyrolipomatosis: 5 case reports and historical review of the literature. Ann Diagn Pathol 2009;13:384-9. [PubMed]
  12. Sheikh SS, Massloom HS. Lipoadenoma: is it arising from thyroid or parathyroid? A diagnostic dilemma. ORL J Otorhinolaryngol Relat Spec 2002;64:448-50. [PubMed]
Cite this article as: Sanuvada RV, Chowhan AK, Rukmangadha N, Patnayak R, Yootla M, Amancharla LY. Thyrolipomatosis: an inquisitive rare entity. Gland Surg 2014;3(4):E6-E9. doi: 10.3978/j.issn.2227-684X.2014.11.02