Article Abstract

Neuroimaging in emergency: a review of possible role of pineal gland disease

Authors: Federico Bruno, Francesco Arrigoni, Nicola Maggialetti, Raffaele Natella, Alfonso Reginelli, Ernesto Di Cesare, Luca Brunese, Andrea Giovagnoni, Carlo Masciocchi, Alessandra Splendiani, Antonio Barile


The pineal gland can be involved in a variety of neoplastic and congenital masses and tumors. Pineal gland neoplasms occur more frequently in children, accounting for 3–8% of intracranial tumors in the pediatric population. Pineal cysts are small lesions usually asymptomatic and encountered incidentally. Pathologic processes involving the pineal region produce signs and symptoms related to the mass effect on the adjacent structures and invasion of surrounding structures. These include several acute symptoms, such as increased intracranial pressure syndrome from obstruction of the aqueduct and consequent hydrocephalus, and Parinaud syndrome. Pineal apoplexy is rare and refers to the sudden neurological deterioration following hemorrhage in the pineal gland, most commonly into a pineal cyst. Knowledge of the clinical presentation and imaging features of these lesions is essential to narrow the differential diagnosis, especially when presenting with acute onset.